Role of Glutathione System Redox Potential in Apoptosis Dysregulation in MCF-7 Breast Adenocarcinoma
- Authors: Shakhristova E.V.1, Stepovaya E.A.1, Ryazantseva N.V.2, Nosareva O.L.1, Yakushina V.D.1, Ivanov V.V.1, Novitskii V.V.1
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Affiliations:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Siberian Federal University
- Issue: Vol 160, No 3 (2016)
- Pages: 364-367
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/236708
- DOI: https://doi.org/10.1007/s10517-016-3172-1
- ID: 236708
Cite item
Abstract
MCF-7 breast cancer cells and HBL-100 breast epithelial cells were cultured with N-ethylmaleimide, a blocker of SH groups. Changes in redox potential of the glutathione system, activities of glutathione reductase, glutathione peroxidase, and intensity of apoptotic cell death were evaluated. The results indicate that incubation with N-ethylmaleimide led to glutathione system imbalance, reduced tumor cell redox potential, and induced their programmed death, which seemed useful for prospective target therapy of tumor diseases.
About the authors
E. V. Shakhristova
Siberian State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: shaxristova@yandex.ru
Russian Federation, Tomsk
E. A. Stepovaya
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Russian Federation, Tomsk
N. V. Ryazantseva
Siberian Federal University
Email: shaxristova@yandex.ru
Russian Federation, Krasnoyarsk
O. L. Nosareva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Russian Federation, Tomsk
V. D. Yakushina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Russian Federation, Tomsk
V. V. Ivanov
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Russian Federation, Tomsk
V. V. Novitskii
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Russian Federation, Tomsk