Role of Glutathione System Redox Potential in Apoptosis Dysregulation in MCF-7 Breast Adenocarcinoma
- Авторы: Shakhristova E.1, Stepovaya E.1, Ryazantseva N.2, Nosareva O.1, Yakushina V.1, Ivanov V.1, Novitskii V.1
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Учреждения:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Siberian Federal University
- Выпуск: Том 160, № 3 (2016)
- Страницы: 364-367
- Раздел: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/236708
- DOI: https://doi.org/10.1007/s10517-016-3172-1
- ID: 236708
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Аннотация
MCF-7 breast cancer cells and HBL-100 breast epithelial cells were cultured with N-ethylmaleimide, a blocker of SH groups. Changes in redox potential of the glutathione system, activities of glutathione reductase, glutathione peroxidase, and intensity of apoptotic cell death were evaluated. The results indicate that incubation with N-ethylmaleimide led to glutathione system imbalance, reduced tumor cell redox potential, and induced their programmed death, which seemed useful for prospective target therapy of tumor diseases.
Об авторах
E. Shakhristova
Siberian State Medical University, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: shaxristova@yandex.ru
Россия, Tomsk
E. Stepovaya
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Россия, Tomsk
N. Ryazantseva
Siberian Federal University
Email: shaxristova@yandex.ru
Россия, Krasnoyarsk
O. Nosareva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Россия, Tomsk
V. Yakushina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Россия, Tomsk
V. Ivanov
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Россия, Tomsk
V. Novitskii
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: shaxristova@yandex.ru
Россия, Tomsk