Combined Effect of Bone Morphogenetic Protein-2 and Erythropoietin on Regeneration of Cranial Bone Defects in Mice


Дәйексөз келтіру

Толық мәтін

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Рұқсат жабық Тек жазылушылар үшін

Аннотация

Using mouse model of regeneration of critical size cranial defects, we studied combined effect of 1 and 10 μg of BMP-2 of prokaryotic origin and recombinant erythropoietin (Epostim) injected subcutaneously in the area of bone defect in a total dose of 6000 U/kg. Erythropoietin considerably improved quantitative and qualitative characteristics of the bone tissue in the site of implantation when used in combination with BMP-2 in both concentrations.

Авторлар туралы

A. Gromov

N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Хат алмасуға жауапты Автор.
Email: alexander.v.gromov@gmail.com
Ресей, Moscow

M. Bartov

N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Email: alexander.v.gromov@gmail.com
Ресей, Moscow

P. Orlova

N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Email: alexander.v.gromov@gmail.com
Ресей, Moscow

V. Manskikh

N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation; A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University

Email: alexander.v.gromov@gmail.com
Ресей, Moscow; Moscow

M. Krivozubov

N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Email: alexander.v.gromov@gmail.com
Ресей, Moscow

T. Grunina

N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Email: alexander.v.gromov@gmail.com
Ресей, Moscow

M. Manukhina

N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Email: alexander.v.gromov@gmail.com
Ресей, Moscow

N. Strukova

N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Email: alexander.v.gromov@gmail.com
Ресей, Moscow

K. Nikitin

N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Email: alexander.v.gromov@gmail.com
Ресей, Moscow

V. Lunin

N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation; All-Russian Research Institute of Agricultural Biotechnology

Email: alexander.v.gromov@gmail.com
Ресей, Moscow; Moscow

A. Karyagina

N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation; A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University; All-Russian Research Institute of Agricultural Biotechnology

Email: alexander.v.gromov@gmail.com
Ресей, Moscow; Moscow; Moscow

A. Gintsburg

N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Email: alexander.v.gromov@gmail.com
Ресей, Moscow


© Springer Science+Business Media, LLC, part of Springer Nature, 2019

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