Enviar artigo por via de e-mail Combined Effect of Bone Morphogenetic Protein-2 and Erythropoietin on Regeneration of Cranial Bone Defects in Mice
- Autores: Gromov A.1, Bartov M.1, Orlova P.1, Manskikh V.1,2, Krivozubov M.1, Grunina T.1, Manukhina M.1, Strukova N.1, Nikitin K.1, Lunin V.1,3, Karyagina A.1,2,3, Gintsburg A.1
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Afiliações:
- N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
- A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
- All-Russian Research Institute of Agricultural Biotechnology
- Edição: Volume 167, Nº 3 (2019)
- Páginas: 408-412
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241763
- DOI: https://doi.org/10.1007/s10517-019-04538-5
- ID: 241763
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Resumo
Using mouse model of regeneration of critical size cranial defects, we studied combined effect of 1 and 10 μg of BMP-2 of prokaryotic origin and recombinant erythropoietin (Epostim) injected subcutaneously in the area of bone defect in a total dose of 6000 U/kg. Erythropoietin considerably improved quantitative and qualitative characteristics of the bone tissue in the site of implantation when used in combination with BMP-2 in both concentrations.
Sobre autores
A. Gromov
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: alexander.v.gromov@gmail.com
Rússia, Moscow
M. Bartov
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Rússia, Moscow
P. Orlova
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Rússia, Moscow
V. Manskikh
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation; A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
Email: alexander.v.gromov@gmail.com
Rússia, Moscow; Moscow
M. Krivozubov
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Rússia, Moscow
T. Grunina
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Rússia, Moscow
M. Manukhina
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Rússia, Moscow
N. Strukova
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Rússia, Moscow
K. Nikitin
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Rússia, Moscow
V. Lunin
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation; All-Russian Research Institute of Agricultural Biotechnology
Email: alexander.v.gromov@gmail.com
Rússia, Moscow; Moscow
A. Karyagina
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation; A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University; All-Russian Research Institute of Agricultural Biotechnology
Email: alexander.v.gromov@gmail.com
Rússia, Moscow; Moscow; Moscow
A. Gintsburg
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: alexander.v.gromov@gmail.com
Rússia, Moscow
