Antidiabetic Activity of Afobazole in Wistar Rats
- Авторлар: Ostrovskaya R.1, Ivanov S.1, Voronin M.1, Ozerova I.1, Zolotov N.1, Seredenin S.1
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Мекемелер:
- V. V. Zakusov Research Institute of Pharmacology
- Шығарылым: Том 165, № 5 (2018)
- Беттер: 649-652
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240628
- DOI: https://doi.org/10.1007/s10517-018-4233-4
- ID: 240628
Дәйексөз келтіру
Аннотация
Using the streptozotocin model of type 2 diabetes mellitus in Wistar rats, we compared antidiabetic activity of anxiolytic Afobazole with that of metformin. Afobazole in a dose of 10 mg/kg reduced streptozotocin-induced hyperglycemia and polyphagia and prevented accumulation of malonic dialdehyde, being not inferior to metformin in a dose of 300 mg/kg, and was even more effective than metformin in body weight recovery, elimination of polydipsia, and preservation of these effects after treatment withdrawal.
Авторлар туралы
R. Ostrovskaya
V. V. Zakusov Research Institute of Pharmacology
Хат алмасуға жауапты Автор.
Email: rita.ostrovskaya@gmail.com
Ресей, Moscow
S. Ivanov
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
Ресей, Moscow
M. Voronin
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
Ресей, Moscow
I. Ozerova
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
Ресей, Moscow
N. Zolotov
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
Ресей, Moscow
S. Seredenin
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
Ресей, Moscow