Antidiabetic Activity of Afobazole in Wistar Rats
- 作者: Ostrovskaya R.1, Ivanov S.1, Voronin M.1, Ozerova I.1, Zolotov N.1, Seredenin S.1
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隶属关系:
- V. V. Zakusov Research Institute of Pharmacology
- 期: 卷 165, 编号 5 (2018)
- 页面: 649-652
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240628
- DOI: https://doi.org/10.1007/s10517-018-4233-4
- ID: 240628
如何引用文章
详细
Using the streptozotocin model of type 2 diabetes mellitus in Wistar rats, we compared antidiabetic activity of anxiolytic Afobazole with that of metformin. Afobazole in a dose of 10 mg/kg reduced streptozotocin-induced hyperglycemia and polyphagia and prevented accumulation of malonic dialdehyde, being not inferior to metformin in a dose of 300 mg/kg, and was even more effective than metformin in body weight recovery, elimination of polydipsia, and preservation of these effects after treatment withdrawal.
作者简介
R. Ostrovskaya
V. V. Zakusov Research Institute of Pharmacology
编辑信件的主要联系方式.
Email: rita.ostrovskaya@gmail.com
俄罗斯联邦, Moscow
S. Ivanov
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
俄罗斯联邦, Moscow
M. Voronin
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
俄罗斯联邦, Moscow
I. Ozerova
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
俄罗斯联邦, Moscow
N. Zolotov
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
俄罗斯联邦, Moscow
S. Seredenin
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
俄罗斯联邦, Moscow