Antidiabetic Activity of Afobazole in Wistar Rats
- Authors: Ostrovskaya R.U.1, Ivanov S.V.1, Voronin M.V.1, Ozerova I.V.1, Zolotov N.N.1, Seredenin S.B.1
-
Affiliations:
- V. V. Zakusov Research Institute of Pharmacology
- Issue: Vol 165, No 5 (2018)
- Pages: 649-652
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240628
- DOI: https://doi.org/10.1007/s10517-018-4233-4
- ID: 240628
Cite item
Abstract
Using the streptozotocin model of type 2 diabetes mellitus in Wistar rats, we compared antidiabetic activity of anxiolytic Afobazole with that of metformin. Afobazole in a dose of 10 mg/kg reduced streptozotocin-induced hyperglycemia and polyphagia and prevented accumulation of malonic dialdehyde, being not inferior to metformin in a dose of 300 mg/kg, and was even more effective than metformin in body weight recovery, elimination of polydipsia, and preservation of these effects after treatment withdrawal.
About the authors
R. U. Ostrovskaya
V. V. Zakusov Research Institute of Pharmacology
Author for correspondence.
Email: rita.ostrovskaya@gmail.com
Russian Federation, Moscow
S. V. Ivanov
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
Russian Federation, Moscow
M. V. Voronin
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
Russian Federation, Moscow
I. V. Ozerova
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
Russian Federation, Moscow
N. N. Zolotov
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
Russian Federation, Moscow
S. B. Seredenin
V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
Russian Federation, Moscow