Discrete Stretch Eliminates Electrophysiological Dose-Dependent Effects of Nitric Oxide Donor SNAP in Rat Atrium
- Авторлар: Shim A.1, Mitrokhin V.1, Kazanski V.1, Mladenov M.1, Kamkin A.1
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Мекемелер:
- Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Шығарылым: Том 163, № 6 (2017)
- Беттер: 705-709
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239211
- DOI: https://doi.org/10.1007/s10517-017-3885-9
- ID: 239211
Дәйексөз келтіру
Аннотация
Depolarization of cardiomyocytes triggered by stretch and activation of mechanically gated ion channels can lead to serious arrhythmias. However, stretch-induced signaling activating these channels remain little studied. This study tested the hypothesis on implication of NO in shaping the electrical abnormalities provoked by stretch of the right atrial myocardium in rat via a mechanism engaging a signaling cascade, where NO plays a significant role. This approach showed that in isolated right atrial preparation, NO donor SNAP induces the electrical abnormalities similar to those provoked by stretch, and the latter results from activation of NO synthase.
Авторлар туралы
A. Shim
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
Ресей, Moscow
V. Mitrokhin
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: vmitrokhin@gmail.com
Ресей, Moscow
V. Kazanski
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
Ресей, Moscow
M. Mladenov
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
Ресей, Moscow
A. Kamkin
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
Ресей, Moscow