Discrete Stretch Eliminates Electrophysiological Dose-Dependent Effects of Nitric Oxide Donor SNAP in Rat Atrium
- Autores: Shim A.1, Mitrokhin V.1, Kazanski V.1, Mladenov M.1, Kamkin A.1
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Afiliações:
- Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Edição: Volume 163, Nº 6 (2017)
- Páginas: 705-709
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239211
- DOI: https://doi.org/10.1007/s10517-017-3885-9
- ID: 239211
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Resumo
Depolarization of cardiomyocytes triggered by stretch and activation of mechanically gated ion channels can lead to serious arrhythmias. However, stretch-induced signaling activating these channels remain little studied. This study tested the hypothesis on implication of NO in shaping the electrical abnormalities provoked by stretch of the right atrial myocardium in rat via a mechanism engaging a signaling cascade, where NO plays a significant role. This approach showed that in isolated right atrial preparation, NO donor SNAP induces the electrical abnormalities similar to those provoked by stretch, and the latter results from activation of NO synthase.
Sobre autores
A. Shim
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
Rússia, Moscow
V. Mitrokhin
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: vmitrokhin@gmail.com
Rússia, Moscow
V. Kazanski
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
Rússia, Moscow
M. Mladenov
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
Rússia, Moscow
A. Kamkin
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
Rússia, Moscow