Discrete Stretch Eliminates Electrophysiological Dose-Dependent Effects of Nitric Oxide Donor SNAP in Rat Atrium
- 作者: Shim A.1, Mitrokhin V.1, Kazanski V.1, Mladenov M.1, Kamkin A.1
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隶属关系:
- Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- 期: 卷 163, 编号 6 (2017)
- 页面: 705-709
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239211
- DOI: https://doi.org/10.1007/s10517-017-3885-9
- ID: 239211
如何引用文章
详细
Depolarization of cardiomyocytes triggered by stretch and activation of mechanically gated ion channels can lead to serious arrhythmias. However, stretch-induced signaling activating these channels remain little studied. This study tested the hypothesis on implication of NO in shaping the electrical abnormalities provoked by stretch of the right atrial myocardium in rat via a mechanism engaging a signaling cascade, where NO plays a significant role. This approach showed that in isolated right atrial preparation, NO donor SNAP induces the electrical abnormalities similar to those provoked by stretch, and the latter results from activation of NO synthase.
作者简介
A. Shim
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
俄罗斯联邦, Moscow
V. Mitrokhin
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: vmitrokhin@gmail.com
俄罗斯联邦, Moscow
V. Kazanski
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
俄罗斯联邦, Moscow
M. Mladenov
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
俄罗斯联邦, Moscow
A. Kamkin
Department of Physiology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vmitrokhin@gmail.com
俄罗斯联邦, Moscow
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