Experimental Assessment of the Effect of Kagocel on Reproductive Function in Pubertal Male Rats
- Авторлар: Borovskaya T.1, Poluektova M.1, Vychuzhanina A.1, Mashanova V.1, Shchemerova Y.1
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Мекемелер:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Шығарылым: Том 163, № 2 (2017)
- Беттер: 214-217
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238760
- DOI: https://doi.org/10.1007/s10517-017-3769-z
- ID: 238760
Дәйексөз келтіру
Аннотация
We studied possible toxic effects of antiviral drug Kagocel on reproductive function in pubertal male rats. The drug was administered in therapeutic and 10-fold higher doses throughout the spermatogenesis cycle (48 days). Kagocel did not reduce mating and fertilizing capacities, did not suppress spermatogenesis, and had no toxic effects on the offspring. The results characterize Kagocel as a drug with a broad reproductive safety profile and demonstrate that the age limits for using Kagocel in pediatric practice can be extended.
Авторлар туралы
T. Borovskaya
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: repropharm@yandex.ru
Ресей, Tomsk
M. Poluektova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Ресей, Tomsk
A. Vychuzhanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Ресей, Tomsk
V. Mashanova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Ресей, Tomsk
Yu. Shchemerova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Ресей, Tomsk