Experimental Assessment of the Effect of Kagocel on Reproductive Function in Pubertal Male Rats
- 作者: Borovskaya T.1, Poluektova M.1, Vychuzhanina A.1, Mashanova V.1, Shchemerova Y.1
-
隶属关系:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- 期: 卷 163, 编号 2 (2017)
- 页面: 214-217
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238760
- DOI: https://doi.org/10.1007/s10517-017-3769-z
- ID: 238760
如何引用文章
详细
We studied possible toxic effects of antiviral drug Kagocel on reproductive function in pubertal male rats. The drug was administered in therapeutic and 10-fold higher doses throughout the spermatogenesis cycle (48 days). Kagocel did not reduce mating and fertilizing capacities, did not suppress spermatogenesis, and had no toxic effects on the offspring. The results characterize Kagocel as a drug with a broad reproductive safety profile and demonstrate that the age limits for using Kagocel in pediatric practice can be extended.
作者简介
T. Borovskaya
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk
M. Poluektova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk
A. Vychuzhanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk
V. Mashanova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk
Yu. Shchemerova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
俄罗斯联邦, Tomsk
![](/img/style/loading.gif)