Experimental Assessment of the Effect of Kagocel on Reproductive Function in Pubertal Male Rats
- Autores: Borovskaya T.1, Poluektova M.1, Vychuzhanina A.1, Mashanova V.1, Shchemerova Y.1
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Afiliações:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Edição: Volume 163, Nº 2 (2017)
- Páginas: 214-217
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238760
- DOI: https://doi.org/10.1007/s10517-017-3769-z
- ID: 238760
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Resumo
We studied possible toxic effects of antiviral drug Kagocel on reproductive function in pubertal male rats. The drug was administered in therapeutic and 10-fold higher doses throughout the spermatogenesis cycle (48 days). Kagocel did not reduce mating and fertilizing capacities, did not suppress spermatogenesis, and had no toxic effects on the offspring. The results characterize Kagocel as a drug with a broad reproductive safety profile and demonstrate that the age limits for using Kagocel in pediatric practice can be extended.
Sobre autores
T. Borovskaya
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Autor responsável pela correspondência
Email: repropharm@yandex.ru
Rússia, Tomsk
M. Poluektova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Rússia, Tomsk
A. Vychuzhanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Rússia, Tomsk
V. Mashanova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Rússia, Tomsk
Yu. Shchemerova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Rússia, Tomsk