Psychopharmacological Effects of JNK Inhibitor in Posthypoxic Encephalopathy and Mechanisms of Their Development
- Авторлар: Zyuz’kov G.1,2, Suslov N.1, Povet’eva T.1, Nesterova Y.1, Afanas’eva O.1, Udut E.1, Miroshnichenko L.1, Simanina E.1, Polyakova T.1, Stavrova L.1, Chaikovskii A.1, Kul’pin P.1, Udut V.1,2, Dygai A.1, Zhdanov V.1
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Мекемелер:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Laboratory for Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University
- Шығарылым: Том 163, № 1 (2017)
- Беттер: 18-21
- Бөлім: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/238615
- DOI: https://doi.org/10.1007/s10517-017-3727-9
- ID: 238615
Дәйексөз келтіру
Аннотация
Psychopharmacological effects of JNK inhibitor were studied using a mouse model of posthypoxic encephalopathy. The preparation exhibited a pronounced cerebroprotective effect manifested in normalization of orientation and exploratory behavior and conditioned responses in posthypoxic mice. These effects were accompanied by marked elevation of neural stem cell content in the paraventricular region of the brain.
Авторлар туралы
G. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences; Laboratory for Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University
Хат алмасуға жауапты Автор.
Email: zgn@pharmso.ru
Ресей, Tomsk; Tomsk
N. Suslov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: zgn@pharmso.ru
Ресей, Tomsk
T. Povet’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: zgn@pharmso.ru
Ресей, Tomsk
Yu. Nesterova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: zgn@pharmso.ru
Ресей, Tomsk
O. Afanas’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: zgn@pharmso.ru
Ресей, Tomsk
E. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: zgn@pharmso.ru
Ресей, Tomsk
L. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: zgn@pharmso.ru
Ресей, Tomsk
E. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: zgn@pharmso.ru
Ресей, Tomsk
T. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: zgn@pharmso.ru
Ресей, Tomsk
L. Stavrova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: zgn@pharmso.ru
Ресей, Tomsk
A. Chaikovskii
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: zgn@pharmso.ru
Ресей, Tomsk
P. Kul’pin
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: zgn@pharmso.ru
Ресей, Tomsk
V. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences; Laboratory for Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University
Email: zgn@pharmso.ru
Ресей, Tomsk; Tomsk
A. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: zgn@pharmso.ru
Ресей, Tomsk
V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: zgn@pharmso.ru
Ресей, Tomsk
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