Psychopharmacological Effects of JNK Inhibitor in Posthypoxic Encephalopathy and Mechanisms of Their Development


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Аннотация

Psychopharmacological effects of JNK inhibitor were studied using a mouse model of posthypoxic encephalopathy. The preparation exhibited a pronounced cerebroprotective effect manifested in normalization of orientation and exploratory behavior and conditioned responses in posthypoxic mice. These effects were accompanied by marked elevation of neural stem cell content in the paraventricular region of the brain.

Авторлар туралы

G. Zyuz’kov

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences; Laboratory for Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University

Хат алмасуға жауапты Автор.
Email: zgn@pharmso.ru
Ресей, Tomsk; Tomsk

N. Suslov

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: zgn@pharmso.ru
Ресей, Tomsk

T. Povet’eva

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: zgn@pharmso.ru
Ресей, Tomsk

Yu. Nesterova

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: zgn@pharmso.ru
Ресей, Tomsk

O. Afanas’eva

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: zgn@pharmso.ru
Ресей, Tomsk

E. Udut

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: zgn@pharmso.ru
Ресей, Tomsk

L. Miroshnichenko

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: zgn@pharmso.ru
Ресей, Tomsk

E. Simanina

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: zgn@pharmso.ru
Ресей, Tomsk

T. Polyakova

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: zgn@pharmso.ru
Ресей, Tomsk

L. Stavrova

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: zgn@pharmso.ru
Ресей, Tomsk

A. Chaikovskii

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: zgn@pharmso.ru
Ресей, Tomsk

P. Kul’pin

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: zgn@pharmso.ru
Ресей, Tomsk

V. Udut

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences; Laboratory for Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University

Email: zgn@pharmso.ru
Ресей, Tomsk; Tomsk

A. Dygai

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: zgn@pharmso.ru
Ресей, Tomsk

V. Zhdanov

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: zgn@pharmso.ru
Ресей, Tomsk

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