Psychopharmacological Effects of JNK Inhibitor in Posthypoxic Encephalopathy and Mechanisms of Their Development

G. N. Zyuz’kov; N. I. Suslov; T. N. Povet’eva; Yu. V. Nesterova; O. G. Afanas’eva; E. V. Udut; L. A. Miroshnichenko; E. V. Simanina; T. Yu. Polyakova; L. A. Stavrova; A. V. Chaikovskii; P. V. Kul’pin; V. V. Udut; A. M. Dygai; V. V. Zhdanov

doi:10.1007/s10517-017-3727-9

Psychopharmacological Effects of JNK Inhibitor in Posthypoxic Encephalopathy and Mechanisms of Their Development

Authors: Zyuz’kov G.N.¹^,2, Suslov N.I.¹, Povet’eva T.N.¹, Nesterova Y.V.¹, Afanas’eva O.G.¹, Udut E.V.¹, Miroshnichenko L.A.¹, Simanina E.V.¹, Polyakova T.Y.¹, Stavrova L.A.¹, Chaikovskii A.V.¹, Kul’pin P.V.¹, Udut V.V.¹^,2, Dygai A.M.¹, Zhdanov V.V.¹
Affiliations:
1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
2. Laboratory for Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University
Issue: Vol 163, No 1 (2017)
Pages: 18-21
Section: General Pathology and Pathophysiology
URL: https://journals.rcsi.science/0007-4888/article/view/238615
DOI: https://doi.org/10.1007/s10517-017-3727-9
ID: 238615

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Abstract

Psychopharmacological effects of JNK inhibitor were studied using a mouse model of posthypoxic encephalopathy. The preparation exhibited a pronounced cerebroprotective effect manifested in normalization of orientation and exploratory behavior and conditioned responses in posthypoxic mice. These effects were accompanied by marked elevation of neural stem cell content in the paraventricular region of the brain.

About the authors

G. N. Zyuz’kov

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences; Laboratory for Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University

Author for correspondence.
Email: zgn@pharmso.ru
Russian Federation, Tomsk; Tomsk

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