Мақаланы E-mail арқылы жіберу Study of Fibronectin Type III-Like Domains Role in Activation of gp130 Receptor
- Авторлар: Stepanov A.1, Rybinets A.1, Dronina M.1, Deev S.1
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Мекемелер:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Шығарылым: Том 161, № 1 (2016)
- Беттер: 72-74
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237109
- DOI: https://doi.org/10.1007/s10517-016-3348-8
- ID: 237109
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Аннотация
Chimeric gp130 receptors were produced to study the role of three fibronectin type III-like domains in activation of gp130 receptor machinery. The ligand-induced dimerization of gp130 was sufficient to trigger STAT3 signaling pathway. These findings can be used as the basis in designing novel therapeutic gp130 inhibitors.
Авторлар туралы
A. Stepanov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: Stepanov.Aleksei.v@gmail.com
Ресей, Moscow
A. Rybinets
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Stepanov.Aleksei.v@gmail.com
Ресей, Moscow
M. Dronina
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Stepanov.Aleksei.v@gmail.com
Ресей, Moscow
S. Deev
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Stepanov.Aleksei.v@gmail.com
Ресей, Moscow
