Отправить статью по E-mail Study of Fibronectin Type III-Like Domains Role in Activation of gp130 Receptor
- Авторы: Stepanov A.1, Rybinets A.1, Dronina M.1, Deev S.1
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Учреждения:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Выпуск: Том 161, № 1 (2016)
- Страницы: 72-74
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237109
- DOI: https://doi.org/10.1007/s10517-016-3348-8
- ID: 237109
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Аннотация
Chimeric gp130 receptors were produced to study the role of three fibronectin type III-like domains in activation of gp130 receptor machinery. The ligand-induced dimerization of gp130 was sufficient to trigger STAT3 signaling pathway. These findings can be used as the basis in designing novel therapeutic gp130 inhibitors.
Об авторах
A. Stepanov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: Stepanov.Aleksei.v@gmail.com
Россия, Moscow
A. Rybinets
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Stepanov.Aleksei.v@gmail.com
Россия, Moscow
M. Dronina
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Stepanov.Aleksei.v@gmail.com
Россия, Moscow
S. Deev
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Stepanov.Aleksei.v@gmail.com
Россия, Moscow
