Email this article Study of Fibronectin Type III-Like Domains Role in Activation of gp130 Receptor
- Authors: Stepanov A.V.1, Rybinets A.S.1, Dronina M.A.1, Deev S.M.1
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Affiliations:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Issue: Vol 161, No 1 (2016)
- Pages: 72-74
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237109
- DOI: https://doi.org/10.1007/s10517-016-3348-8
- ID: 237109
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Abstract
Chimeric gp130 receptors were produced to study the role of three fibronectin type III-like domains in activation of gp130 receptor machinery. The ligand-induced dimerization of gp130 was sufficient to trigger STAT3 signaling pathway. These findings can be used as the basis in designing novel therapeutic gp130 inhibitors.
About the authors
A. V. Stepanov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: Stepanov.Aleksei.v@gmail.com
Russian Federation, Moscow
A. S. Rybinets
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Stepanov.Aleksei.v@gmail.com
Russian Federation, Moscow
M. A. Dronina
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Stepanov.Aleksei.v@gmail.com
Russian Federation, Moscow
S. M. Deev
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: Stepanov.Aleksei.v@gmail.com
Russian Federation, Moscow
