Psychopharmacological Effects of Alkaloid Z77 under Conditions of Posthypoxic Encephalopathy and Mechanisms of Their Development
- Авторлар: Zyuz’kov G.1,2, Losev E.1, Chaikovskii A.1, Suslov N.1, Zhdanov V.1, Udut E.1, Miroshnichenko L.1, Simanina E.1, Polyakova T.1, Povet’eva T.1, Nesterova Y.1, Stavrova L.1, Udut V.1,2, Minakova M.1, Dygai A.1
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Мекемелер:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Tomsk National Research State University
- Шығарылым: Том 161, № 1 (2016)
- Беттер: 45-49
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237078
- DOI: https://doi.org/10.1007/s10517-016-3341-2
- ID: 237078
Дәйексөз келтіру
Аннотация
Psychopharmacological effects of atisine-type diterpene alkaloid Z77 were studied under conditions of experimental posthypoxic encephalopathy. The preparation had a pronounced cerebroprotective effect consisting in normalization of orientation and exploratory behavior and conditioned activity in experimental animals. These changes were accompanied by significant increase in the number of neural stem cells in the paraventricular region of the brain and markedly enhanced production of neurotrophic growth factors by neural tissue microenvironment cells.
Авторлар туралы
G. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; Tomsk National Research State University
Хат алмасуға жауапты Автор.
Email: zgn@pharm.tsu.ru
Ресей, Tomsk; Tomsk
E. Losev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Ресей, Tomsk
A. Chaikovskii
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Ресей, Tomsk
N. Suslov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Ресей, Tomsk
V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Ресей, Tomsk
E. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Ресей, Tomsk
L. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Ресей, Tomsk
E. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Ресей, Tomsk
T. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Ресей, Tomsk
T. Povet’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Ресей, Tomsk
Yu. Nesterova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Ресей, Tomsk
L. Stavrova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Ресей, Tomsk
V. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; Tomsk National Research State University
Email: zgn@pharm.tsu.ru
Ресей, Tomsk; Tomsk
M. Minakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Ресей, Tomsk
A. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharm.tsu.ru
Ресей, Tomsk