Depression of Macrophages Modifies Serum Lipid Profile in Hyperlipidemia
- Авторлар: Goncharova N.1, Pupyshev A.2, Filyushina E.1, Loktev K.1, Korolenko E.3, Lushnikova E.4, Molodykh O.4, Korolenko T.1, Churin B.4
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Мекемелер:
- Institute of Physiology and Basic Medicine
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- University Canada West
- Institute of Molecular Pathology and Pathomorphology
- Шығарылым: Том 160, № 5 (2016)
- Беттер: 617-621
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236840
- DOI: https://doi.org/10.1007/s10517-016-3231-7
- ID: 236840
Дәйексөз келтіру
Аннотация
Suppression of functional activity of macrophages by gadolinium chloride, suppressing the macrophage population and the endocytosis velocity, was studied in vivo. Injection of GdCl3 led to an increase in serum cholesterol concentration. Preliminary injection of GdCl3 to mice with lipidemia 24 h before poloxamer 407 reduced the concentrations of triglycerides and LDL during marked depression of macrophages (in 24 h). Macrophage repopulation (days 5, 7) was associated with development of a trend to an increase of triglyceride and LDL levels. lectron microscopic study of Kupffer cells after injection of poloxamer 407 and its combination with gadoliniun chloride detected the intralysosomal accumulation syndrome in these cells (formation of auto- and heterophagolysosomes). Activity of cathepsin B, characteristic of macrophages, reduced 24 h after injections of GdCl3 and poloxamer 407 alone and restored in response to their combination.
Авторлар туралы
N. Goncharova
Institute of Physiology and Basic Medicine
Хат алмасуға жауапты Автор.
Email: pathol@inbox.ru
Ресей, Novosibirsk
A. Pupyshev
Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Email: pathol@inbox.ru
Ресей, Novosibirsk
E. Filyushina
Institute of Physiology and Basic Medicine
Email: pathol@inbox.ru
Ресей, Novosibirsk
K. Loktev
Institute of Physiology and Basic Medicine
Email: pathol@inbox.ru
Ресей, Novosibirsk
E. Korolenko
University Canada West
Email: pathol@inbox.ru
Канада, Vancouver
E. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Ресей, Novosibirsk
O. Molodykh
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Ресей, Novosibirsk
T. Korolenko
Institute of Physiology and Basic Medicine
Email: pathol@inbox.ru
Ресей, Novosibirsk
B. Churin
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Ресей, Novosibirsk
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