Depression of Macrophages Modifies Serum Lipid Profile in Hyperlipidemia
- 作者: Goncharova N.1, Pupyshev A.2, Filyushina E.1, Loktev K.1, Korolenko E.3, Lushnikova E.4, Molodykh O.4, Korolenko T.1, Churin B.4
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隶属关系:
- Institute of Physiology and Basic Medicine
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- University Canada West
- Institute of Molecular Pathology and Pathomorphology
- 期: 卷 160, 编号 5 (2016)
- 页面: 617-621
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236840
- DOI: https://doi.org/10.1007/s10517-016-3231-7
- ID: 236840
如何引用文章
详细
Suppression of functional activity of macrophages by gadolinium chloride, suppressing the macrophage population and the endocytosis velocity, was studied in vivo. Injection of GdCl3 led to an increase in serum cholesterol concentration. Preliminary injection of GdCl3 to mice with lipidemia 24 h before poloxamer 407 reduced the concentrations of triglycerides and LDL during marked depression of macrophages (in 24 h). Macrophage repopulation (days 5, 7) was associated with development of a trend to an increase of triglyceride and LDL levels. lectron microscopic study of Kupffer cells after injection of poloxamer 407 and its combination with gadoliniun chloride detected the intralysosomal accumulation syndrome in these cells (formation of auto- and heterophagolysosomes). Activity of cathepsin B, characteristic of macrophages, reduced 24 h after injections of GdCl3 and poloxamer 407 alone and restored in response to their combination.
作者简介
N. Goncharova
Institute of Physiology and Basic Medicine
编辑信件的主要联系方式.
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
A. Pupyshev
Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
E. Filyushina
Institute of Physiology and Basic Medicine
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
K. Loktev
Institute of Physiology and Basic Medicine
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
E. Korolenko
University Canada West
Email: pathol@inbox.ru
加拿大, Vancouver
E. Lushnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
O. Molodykh
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
T. Korolenko
Institute of Physiology and Basic Medicine
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
B. Churin
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
俄罗斯联邦, Novosibirsk
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