Predictive Models for the Risk of Dyslipidemia in Adolescents with Essential Arterial Hypertension
- Authors: Kalyuzhnaya O.V.1, Bairova T.A.1, Kolesnikova L.I.1
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Affiliations:
- Research Centre for the Problems of Family Health and Human Reproduction
- Issue: Vol 166, No 2 (2018)
- Pages: 297-300
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240980
- DOI: https://doi.org/10.1007/s10517-018-4336-y
- ID: 240980
Cite item
Abstract
Predictive models of comorbidity, dyslipidemic disorders and essential arterial hypertension, in Russian adolescents aged 12 to 18 years (mean 15.48±1.53) were formulated with consideration for biochemical (lipid profiles) and genetic parameters (carrier state of gene polymorphic variants of apolipoprotein genes ApoA1 (-75G/A and +83C/T), ApoB (Ins/Del), ApoC3 (S1/S2), and ApoE (ε2/ε3/ε4). Significant prognostic risk factors for the mentioned comorbid pathologies were lipid metabolism parameters HDL-Ch, LDL-Ch, VLDL-Ch and carrier state of the +83T allele of the ApoA1 gene and Del allele of the ApoB gene. The obtained mathematical model is characterized by high predictive accuracy: the percentage of correct classification or the rate of correct assignment of each participant to the proper group was 96.33%.
About the authors
O. V. Kalyuzhnaya
Research Centre for the Problems of Family Health and Human Reproduction
Author for correspondence.
Email: kaluzhnayao@yandex.ru
Russian Federation, Irkutsk
T. A. Bairova
Research Centre for the Problems of Family Health and Human Reproduction
Email: kaluzhnayao@yandex.ru
Russian Federation, Irkutsk
L. I. Kolesnikova
Research Centre for the Problems of Family Health and Human Reproduction
Email: kaluzhnayao@yandex.ru
Russian Federation, Irkutsk