Predictive Models for the Risk of Dyslipidemia in Adolescents with Essential Arterial Hypertension
- 作者: Kalyuzhnaya O.1, Bairova T.1, Kolesnikova L.1
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隶属关系:
- Research Centre for the Problems of Family Health and Human Reproduction
- 期: 卷 166, 编号 2 (2018)
- 页面: 297-300
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240980
- DOI: https://doi.org/10.1007/s10517-018-4336-y
- ID: 240980
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详细
Predictive models of comorbidity, dyslipidemic disorders and essential arterial hypertension, in Russian adolescents aged 12 to 18 years (mean 15.48±1.53) were formulated with consideration for biochemical (lipid profiles) and genetic parameters (carrier state of gene polymorphic variants of apolipoprotein genes ApoA1 (-75G/A and +83C/T), ApoB (Ins/Del), ApoC3 (S1/S2), and ApoE (ε2/ε3/ε4). Significant prognostic risk factors for the mentioned comorbid pathologies were lipid metabolism parameters HDL-Ch, LDL-Ch, VLDL-Ch and carrier state of the +83T allele of the ApoA1 gene and Del allele of the ApoB gene. The obtained mathematical model is characterized by high predictive accuracy: the percentage of correct classification or the rate of correct assignment of each participant to the proper group was 96.33%.
作者简介
O. Kalyuzhnaya
Research Centre for the Problems of Family Health and Human Reproduction
编辑信件的主要联系方式.
Email: kaluzhnayao@yandex.ru
俄罗斯联邦, Irkutsk
T. Bairova
Research Centre for the Problems of Family Health and Human Reproduction
Email: kaluzhnayao@yandex.ru
俄罗斯联邦, Irkutsk
L. Kolesnikova
Research Centre for the Problems of Family Health and Human Reproduction
Email: kaluzhnayao@yandex.ru
俄罗斯联邦, Irkutsk