Dynamics of Distribution of Capillaries with Matrix Metalloproteinase-2 and Its Tissue Inhibitor in Rat Brain during Development of Experimental Hypertension
- Authors: Chertok V.M.1, Chertok A.G.1, Zakharchuk N.V.2, Nevzorova V.A.2
-
Affiliations:
- Department of Human Anatomy
- Institute of Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 164, No 3 (2018)
- Pages: 397-401
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239641
- DOI: https://doi.org/10.1007/s10517-018-3998-9
- ID: 239641
Cite item
Abstract
The capillaries containing MMP-2 and its tissue inhibitor TIMP-2 were examined in cerebral cortex and white matter obtained from intact Wistar rats (n=5) and the rats with progressing experimental renovascular hypertension (n=35). In hypertensive rats, the changes in intensity of the immunohistochemical reaction and in the density of capillaries expressing TIMP-2 significantly differed from the corresponding values in MMP-2-positive capillaries, which resulted in pronounced deviation of MMP-2/TIMP-2 index from the control level (especially in cerebral cortex) probably attesting to enhanced risk of complications in cases with arterial hypertension.
About the authors
V. M. Chertok
Department of Human Anatomy
Author for correspondence.
Email: chertonv@mail.ru
Russian Federation, Vladivostok
A. G. Chertok
Department of Human Anatomy
Email: chertonv@mail.ru
Russian Federation, Vladivostok
N. V. Zakharchuk
Institute of Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation
Email: chertonv@mail.ru
Russian Federation, Vladivostok
V. A. Nevzorova
Institute of Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation
Email: chertonv@mail.ru
Russian Federation, Vladivostok