Dynamics of Distribution of Capillaries with Matrix Metalloproteinase-2 and Its Tissue Inhibitor in Rat Brain during Development of Experimental Hypertension
- 作者: Chertok V.1, Chertok A.1, Zakharchuk N.2, Nevzorova V.2
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隶属关系:
- Department of Human Anatomy
- Institute of Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation
- 期: 卷 164, 编号 3 (2018)
- 页面: 397-401
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239641
- DOI: https://doi.org/10.1007/s10517-018-3998-9
- ID: 239641
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详细
The capillaries containing MMP-2 and its tissue inhibitor TIMP-2 were examined in cerebral cortex and white matter obtained from intact Wistar rats (n=5) and the rats with progressing experimental renovascular hypertension (n=35). In hypertensive rats, the changes in intensity of the immunohistochemical reaction and in the density of capillaries expressing TIMP-2 significantly differed from the corresponding values in MMP-2-positive capillaries, which resulted in pronounced deviation of MMP-2/TIMP-2 index from the control level (especially in cerebral cortex) probably attesting to enhanced risk of complications in cases with arterial hypertension.
作者简介
V. Chertok
Department of Human Anatomy
编辑信件的主要联系方式.
Email: chertonv@mail.ru
俄罗斯联邦, Vladivostok
A. Chertok
Department of Human Anatomy
Email: chertonv@mail.ru
俄罗斯联邦, Vladivostok
N. Zakharchuk
Institute of Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation
Email: chertonv@mail.ru
俄罗斯联邦, Vladivostok
V. Nevzorova
Institute of Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation
Email: chertonv@mail.ru
俄罗斯联邦, Vladivostok