Dynamics of Distribution of Capillaries with Matrix Metalloproteinase-2 and Its Tissue Inhibitor in Rat Brain during Development of Experimental Hypertension
- Авторлар: Chertok V.1, Chertok A.1, Zakharchuk N.2, Nevzorova V.2
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Мекемелер:
- Department of Human Anatomy
- Institute of Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation
- Шығарылым: Том 164, № 3 (2018)
- Беттер: 397-401
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239641
- DOI: https://doi.org/10.1007/s10517-018-3998-9
- ID: 239641
Дәйексөз келтіру
Аннотация
The capillaries containing MMP-2 and its tissue inhibitor TIMP-2 were examined in cerebral cortex and white matter obtained from intact Wistar rats (n=5) and the rats with progressing experimental renovascular hypertension (n=35). In hypertensive rats, the changes in intensity of the immunohistochemical reaction and in the density of capillaries expressing TIMP-2 significantly differed from the corresponding values in MMP-2-positive capillaries, which resulted in pronounced deviation of MMP-2/TIMP-2 index from the control level (especially in cerebral cortex) probably attesting to enhanced risk of complications in cases with arterial hypertension.
Авторлар туралы
V. Chertok
Department of Human Anatomy
Хат алмасуға жауапты Автор.
Email: chertonv@mail.ru
Ресей, Vladivostok
A. Chertok
Department of Human Anatomy
Email: chertonv@mail.ru
Ресей, Vladivostok
N. Zakharchuk
Institute of Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation
Email: chertonv@mail.ru
Ресей, Vladivostok
V. Nevzorova
Institute of Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation
Email: chertonv@mail.ru
Ресей, Vladivostok