Non-Competitive NMDA Receptor Antagonist Hemantane Reduces Ethanol Consumption in Long-Term Alcohol Experienced Rats
- Authors: Kolik L.G.1, Nadorova A.V.1, Seredenin S.B.1
-
Affiliations:
- V. V. Zakusov Research Institute of Pharmacology
- Issue: Vol 164, No 2 (2017)
- Pages: 152-157
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/239434
- DOI: https://doi.org/10.1007/s10517-017-3946-0
- ID: 239434
Cite item
Abstract
Activity of hemantane, an amino adamantane derivative, exhibiting the properties of lowaffinity non-competitive NMDA receptor antagonist, was evaluated in experimental in vivo models of alcoholism. Hemantane had no effects on the formation and manifestation of behavioral sensitization to ethanol in DBA/2 mice. Under conditions of free choice between 10% ethanol and water, hemantane (20 mg/kg/day for 14 days, intraperitoneally) significantly reduced the daily ethanol intake in random-bred male rats with formed alcohol motivation (>4 g/kg of ethanol). During modelling of withdrawal syndrome, hemantane administered intraperitoneally in doses of 5-20 mg/kg dose-dependently attenuated alcohol-deprivation effect after acute withdrawal with no effects on protracted abstinence. It was found that hemantane suppressed alcohol drinking behavior in long-term ethanol experienced rats and attenuated alcohol-seeking behavior after acute withdrawal.
About the authors
L. G. Kolik
V. V. Zakusov Research Institute of Pharmacology
Author for correspondence.
Email: lgkolik@mail.ru
Russian Federation, Moscow
A. V. Nadorova
V. V. Zakusov Research Institute of Pharmacology
Email: lgkolik@mail.ru
Russian Federation, Moscow
S. B. Seredenin
V. V. Zakusov Research Institute of Pharmacology
Email: lgkolik@mail.ru
Russian Federation, Moscow