Non-Competitive NMDA Receptor Antagonist Hemantane Reduces Ethanol Consumption in Long-Term Alcohol Experienced Rats
- Autores: Kolik L.1, Nadorova A.1, Seredenin S.1
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Afiliações:
- V. V. Zakusov Research Institute of Pharmacology
- Edição: Volume 164, Nº 2 (2017)
- Páginas: 152-157
- Seção: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/239434
- DOI: https://doi.org/10.1007/s10517-017-3946-0
- ID: 239434
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Resumo
Activity of hemantane, an amino adamantane derivative, exhibiting the properties of lowaffinity non-competitive NMDA receptor antagonist, was evaluated in experimental in vivo models of alcoholism. Hemantane had no effects on the formation and manifestation of behavioral sensitization to ethanol in DBA/2 mice. Under conditions of free choice between 10% ethanol and water, hemantane (20 mg/kg/day for 14 days, intraperitoneally) significantly reduced the daily ethanol intake in random-bred male rats with formed alcohol motivation (>4 g/kg of ethanol). During modelling of withdrawal syndrome, hemantane administered intraperitoneally in doses of 5-20 mg/kg dose-dependently attenuated alcohol-deprivation effect after acute withdrawal with no effects on protracted abstinence. It was found that hemantane suppressed alcohol drinking behavior in long-term ethanol experienced rats and attenuated alcohol-seeking behavior after acute withdrawal.
Sobre autores
L. Kolik
V. V. Zakusov Research Institute of Pharmacology
Autor responsável pela correspondência
Email: lgkolik@mail.ru
Rússia, Moscow
A. Nadorova
V. V. Zakusov Research Institute of Pharmacology
Email: lgkolik@mail.ru
Rússia, Moscow
S. Seredenin
V. V. Zakusov Research Institute of Pharmacology
Email: lgkolik@mail.ru
Rússia, Moscow