Activities of Proline-Specific Proteinases in the Serum and Cerebrospinal Fluid of Rats with the Fetal Valproate Syndrome
- Authors: Ivanova E.A.1, Kapitsa I.G.1, Zolotov N.N.1, Pozdnev V.F.2, Voronina T.A.1
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Affiliations:
- V. V. Zakusov Research Institute of Pharmacology
- V. N. Orekhovich Research Institute of Biomedical Chemistry
- Issue: Vol 163, No 5 (2017)
- Pages: 605-607
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239119
- DOI: https://doi.org/10.1007/s10517-017-3859-y
- ID: 239119
Cite item
Abstract
In 60-day-old Wistar rats with fetal valproate syndrome, the brain to body weight ratio was higher by 9.4% and activity of dipeptidyl peptidase IV in the serum and cerebrospinal fluid was higher by 18.4 and 40.6%, respectively, than in healthy controls. Activity of prolylendopeptidase in the serum and cerebrospinal fluid in rats with the fetal valproate syndrome did not differ from the control.
About the authors
E. A. Ivanova
V. V. Zakusov Research Institute of Pharmacology
Author for correspondence.
Email: iwanowaea@yandex.ru
Russian Federation, Moscow
I. G. Kapitsa
V. V. Zakusov Research Institute of Pharmacology
Email: iwanowaea@yandex.ru
Russian Federation, Moscow
N. N. Zolotov
V. V. Zakusov Research Institute of Pharmacology
Email: iwanowaea@yandex.ru
Russian Federation, Moscow
V. F. Pozdnev
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: iwanowaea@yandex.ru
Russian Federation, Moscow
T. A. Voronina
V. V. Zakusov Research Institute of Pharmacology
Email: iwanowaea@yandex.ru
Russian Federation, Moscow