Activities of Proline-Specific Proteinases in the Serum and Cerebrospinal Fluid of Rats with the Fetal Valproate Syndrome

E. A. Ivanova; I. G. Kapitsa; N. N. Zolotov; V. F. Pozdnev; T. A. Voronina

doi:10.1007/s10517-017-3859-y

Activities of Proline-Specific Proteinases in the Serum and Cerebrospinal Fluid of Rats with the Fetal Valproate Syndrome

Авторы: Ivanova E.¹, Kapitsa I.¹, Zolotov N.¹, Pozdnev V.², Voronina T.¹
Учреждения:
1. V. V. Zakusov Research Institute of Pharmacology
2. V. N. Orekhovich Research Institute of Biomedical Chemistry
Выпуск: Том 163, № 5 (2017)
Страницы: 605-607
Раздел: Article
URL: https://journals.rcsi.science/0007-4888/article/view/239119
DOI: https://doi.org/10.1007/s10517-017-3859-y
ID: 239119

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Аннотация

In 60-day-old Wistar rats with fetal valproate syndrome, the brain to body weight ratio was higher by 9.4% and activity of dipeptidyl peptidase IV in the serum and cerebrospinal fluid was higher by 18.4 and 40.6%, respectively, than in healthy controls. Activity of prolylendopeptidase in the serum and cerebrospinal fluid in rats with the fetal valproate syndrome did not differ from the control.