Activities of Proline-Specific Proteinases in the Serum and Cerebrospinal Fluid of Rats with the Fetal Valproate Syndrome

E. A. Ivanova; I. G. Kapitsa; N. N. Zolotov; V. F. Pozdnev; T. A. Voronina

doi:10.1007/s10517-017-3859-y

Activities of Proline-Specific Proteinases in the Serum and Cerebrospinal Fluid of Rats with the Fetal Valproate Syndrome

Authors: Ivanova E.A.¹, Kapitsa I.G.¹, Zolotov N.N.¹, Pozdnev V.F.², Voronina T.A.¹
Affiliations:
1. V. V. Zakusov Research Institute of Pharmacology
2. V. N. Orekhovich Research Institute of Biomedical Chemistry
Issue: Vol 163, No 5 (2017)
Pages: 605-607
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/239119
DOI: https://doi.org/10.1007/s10517-017-3859-y
ID: 239119

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Abstract

In 60-day-old Wistar rats with fetal valproate syndrome, the brain to body weight ratio was higher by 9.4% and activity of dipeptidyl peptidase IV in the serum and cerebrospinal fluid was higher by 18.4 and 40.6%, respectively, than in healthy controls. Activity of prolylendopeptidase in the serum and cerebrospinal fluid in rats with the fetal valproate syndrome did not differ from the control.