Selective Cytotoxicity of Manganese Nanoparticles against Human Glioblastoma Cells
- Authors: Razumov I.A.1, Zav’yalov E.L.1, Troitskii S.Y.2, Romashchenko A.V.1, Petrovskii D.V.1, Kuper K.E.3, Moshkin M.P.1
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Affiliations:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- G. K. Boreskov Institute of Catalysis, Siberian Division of the Russian Academy of Sciences
- G. I. Budker Institute of Nuclear Physics, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 163, No 4 (2017)
- Pages: 561-565
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/239089
- DOI: https://doi.org/10.1007/s10517-017-3849-0
- ID: 239089
Cite item
Abstract
Toxicity of different types of manganese nanoparticles against glioblastoma U-87MG and U-251 cells and normal human cells was studied using MTT test. The selectivity of the toxic effect of nanoparticles was evaluated as the ratio of 50% cytotoxic concentration (СС50) for human embryos fibroblasts (FECh-15) to their СС50 for tumor cells. Five of 6 samples of tested nanoparticles demonstrated selective toxic effect in vitro. Manganese oxide nanoparticles were characterized by maximum selectivity (СС50 6.9 nM and 2.1 nM for U-87MG and U-251 cells, respectively): selectivity index for glioblastoma U-87MG and U-251 cells was 29 and 95.2, respectively. Manganese oxide nanoparticles used for MRI detection of gliomas can be used for designing an oncolytic agent for the treatment of glial tumors in humans.
About the authors
I. A. Razumov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: razumov@bionet.nsc.ru
Russian Federation, Novosibirsk
E. L. Zav’yalov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
Russian Federation, Novosibirsk
S. Yu. Troitskii
G. K. Boreskov Institute of Catalysis, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
Russian Federation, Novosibirsk
A. V. Romashchenko
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
Russian Federation, Novosibirsk
D. V. Petrovskii
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
Russian Federation, Novosibirsk
K. E. Kuper
G. I. Budker Institute of Nuclear Physics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
Russian Federation, Novosibirsk
M. P. Moshkin
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
Russian Federation, Novosibirsk