Selective Cytotoxicity of Manganese Nanoparticles against Human Glioblastoma Cells
- 作者: Razumov I.1, Zav’yalov E.1, Troitskii S.2, Romashchenko A.1, Petrovskii D.1, Kuper K.3, Moshkin M.1
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隶属关系:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- G. K. Boreskov Institute of Catalysis, Siberian Division of the Russian Academy of Sciences
- G. I. Budker Institute of Nuclear Physics, Siberian Division of the Russian Academy of Sciences
- 期: 卷 163, 编号 4 (2017)
- 页面: 561-565
- 栏目: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/239089
- DOI: https://doi.org/10.1007/s10517-017-3849-0
- ID: 239089
如何引用文章
详细
Toxicity of different types of manganese nanoparticles against glioblastoma U-87MG and U-251 cells and normal human cells was studied using MTT test. The selectivity of the toxic effect of nanoparticles was evaluated as the ratio of 50% cytotoxic concentration (СС50) for human embryos fibroblasts (FECh-15) to their СС50 for tumor cells. Five of 6 samples of tested nanoparticles demonstrated selective toxic effect in vitro. Manganese oxide nanoparticles were characterized by maximum selectivity (СС50 6.9 nM and 2.1 nM for U-87MG and U-251 cells, respectively): selectivity index for glioblastoma U-87MG and U-251 cells was 29 and 95.2, respectively. Manganese oxide nanoparticles used for MRI detection of gliomas can be used for designing an oncolytic agent for the treatment of glial tumors in humans.
作者简介
I. Razumov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: razumov@bionet.nsc.ru
俄罗斯联邦, Novosibirsk
E. Zav’yalov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
俄罗斯联邦, Novosibirsk
S. Troitskii
G. K. Boreskov Institute of Catalysis, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
俄罗斯联邦, Novosibirsk
A. Romashchenko
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
俄罗斯联邦, Novosibirsk
D. Petrovskii
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
俄罗斯联邦, Novosibirsk
K. Kuper
G. I. Budker Institute of Nuclear Physics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
俄罗斯联邦, Novosibirsk
M. Moshkin
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
俄罗斯联邦, Novosibirsk