Selective Cytotoxicity of Manganese Nanoparticles against Human Glioblastoma Cells
- Авторы: Razumov I.1, Zav’yalov E.1, Troitskii S.2, Romashchenko A.1, Petrovskii D.1, Kuper K.3, Moshkin M.1
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Учреждения:
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- G. K. Boreskov Institute of Catalysis, Siberian Division of the Russian Academy of Sciences
- G. I. Budker Institute of Nuclear Physics, Siberian Division of the Russian Academy of Sciences
- Выпуск: Том 163, № 4 (2017)
- Страницы: 561-565
- Раздел: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/239089
- DOI: https://doi.org/10.1007/s10517-017-3849-0
- ID: 239089
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Аннотация
Toxicity of different types of manganese nanoparticles against glioblastoma U-87MG and U-251 cells and normal human cells was studied using MTT test. The selectivity of the toxic effect of nanoparticles was evaluated as the ratio of 50% cytotoxic concentration (СС50) for human embryos fibroblasts (FECh-15) to their СС50 for tumor cells. Five of 6 samples of tested nanoparticles demonstrated selective toxic effect in vitro. Manganese oxide nanoparticles were characterized by maximum selectivity (СС50 6.9 nM and 2.1 nM for U-87MG and U-251 cells, respectively): selectivity index for glioblastoma U-87MG and U-251 cells was 29 and 95.2, respectively. Manganese oxide nanoparticles used for MRI detection of gliomas can be used for designing an oncolytic agent for the treatment of glial tumors in humans.
Об авторах
I. Razumov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Автор, ответственный за переписку.
Email: razumov@bionet.nsc.ru
Россия, Novosibirsk
E. Zav’yalov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
Россия, Novosibirsk
S. Troitskii
G. K. Boreskov Institute of Catalysis, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
Россия, Novosibirsk
A. Romashchenko
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
Россия, Novosibirsk
D. Petrovskii
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
Россия, Novosibirsk
K. Kuper
G. I. Budker Institute of Nuclear Physics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
Россия, Novosibirsk
M. Moshkin
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: razumov@bionet.nsc.ru
Россия, Novosibirsk