Cardiovascular Effects of High-Molecular-Weight Compounds of Humic Nature
- Authors: Zykova M.V.1, Belousov M.V.1, Lasukova T.V.2,3, Gorbunov A.S.3, Logvinova L.A.1, Dygai A.M.4
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Affiliations:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Tomsk State Pedagogical University, Ministry of Science and Education
- Research Institute of Cardiology
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Issue: Vol 163, No 2 (2017)
- Pages: 206-209
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/238755
- DOI: https://doi.org/10.1007/s10517-017-3767-1
- ID: 238755
Cite item
Abstract
The active ingredient extracted from the peat humic substances was characterized by physicochemical parameters evaluated by UV- and IR-spectroscopy, titration, and elemental (C, H, N) analysis. The cardiovascular effects of this ingredient were examined on isolated Langendorff-perfused rat heart. It was found that the active substance in a concentration range of 0.01-0.1 mg/ml produced a vasodilating effect; in addition, it decreased the end-diastolic and left-ventricular developed pressures.
About the authors
M. V. Zykova
Siberian State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: gmv2@rambler.ru
Russian Federation, Tomsk
M. V. Belousov
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: gmv2@rambler.ru
Russian Federation, Tomsk
T. V. Lasukova
Tomsk State Pedagogical University, Ministry of Science and Education; Research Institute of Cardiology
Email: gmv2@rambler.ru
Russian Federation, Tomsk; Tomsk
A. S. Gorbunov
Research Institute of Cardiology
Email: gmv2@rambler.ru
Russian Federation, Tomsk
L. A. Logvinova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: gmv2@rambler.ru
Russian Federation, Tomsk
A. M. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: gmv2@rambler.ru
Russian Federation, Tomsk