Neuropeptide Cycloprolylglycine Exhibits Neuroprotective Activity after Systemic Administration to Rats with Modeled Incomplete Global Ischemia and in In Vitro Modeled Glutamate Neurotoxicity
- Authors: Povarnina P.Y.1, Kolyasnikova K.N.1, Nikolaev S.V.2, Antipova T.A.2, Gudasheva T.A.1
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Affiliations:
- Laboratory of Peptide Bioregulators
- Laboratory of Pharmacology of Neuroprotection, V. V. Zakusov Research Institute of Pharmacology
- Issue: Vol 160, No 5 (2016)
- Pages: 653-655
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236862
- DOI: https://doi.org/10.1007/s10517-016-3241-5
- ID: 236862
Cite item
Abstract
We studied cerebroprotective properties of neuropeptide cycloprolylglycine (1 mg/kg) administered intraperitoneally to rats with modeled incomplete global ischemia rats and neuroprotective properties for HT-22 cells under conditions of glutamate toxicity. It was shown that the neuropeptide administered during the postischemic period restored the neurological status of rats by preventing sensorimotor impairments in the limb-placing test and suppression of locomotor activity in the open field test. In in vitro experiments, cycloprolylglycine in concentrations of 10–5-10–8 M exhibited pronounced dose-dependent neuroprotective activity. The results attest to high cerebro- and neuroprotective potential of endogenous peptide cycloprolylglycine.
About the authors
P. Yu. Povarnina
Laboratory of Peptide Bioregulators
Author for correspondence.
Email: povarnina@gmail.com
Russian Federation, Moscow
K. N. Kolyasnikova
Laboratory of Peptide Bioregulators
Email: povarnina@gmail.com
Russian Federation, Moscow
S. V. Nikolaev
Laboratory of Pharmacology of Neuroprotection, V. V. Zakusov Research Institute of Pharmacology
Email: povarnina@gmail.com
Russian Federation, Moscow
T. A. Antipova
Laboratory of Pharmacology of Neuroprotection, V. V. Zakusov Research Institute of Pharmacology
Email: povarnina@gmail.com
Russian Federation, Moscow
T. A. Gudasheva
Laboratory of Peptide Bioregulators
Email: povarnina@gmail.com
Russian Federation, Moscow