Neuropeptide Cycloprolylglycine Exhibits Neuroprotective Activity after Systemic Administration to Rats with Modeled Incomplete Global Ischemia and in In Vitro Modeled Glutamate Neurotoxicity
- Авторы: Povarnina P.1, Kolyasnikova K.1, Nikolaev S.2, Antipova T.2, Gudasheva T.1
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Учреждения:
- Laboratory of Peptide Bioregulators
- Laboratory of Pharmacology of Neuroprotection, V. V. Zakusov Research Institute of Pharmacology
- Выпуск: Том 160, № 5 (2016)
- Страницы: 653-655
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236862
- DOI: https://doi.org/10.1007/s10517-016-3241-5
- ID: 236862
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Аннотация
We studied cerebroprotective properties of neuropeptide cycloprolylglycine (1 mg/kg) administered intraperitoneally to rats with modeled incomplete global ischemia rats and neuroprotective properties for HT-22 cells under conditions of glutamate toxicity. It was shown that the neuropeptide administered during the postischemic period restored the neurological status of rats by preventing sensorimotor impairments in the limb-placing test and suppression of locomotor activity in the open field test. In in vitro experiments, cycloprolylglycine in concentrations of 10–5-10–8 M exhibited pronounced dose-dependent neuroprotective activity. The results attest to high cerebro- and neuroprotective potential of endogenous peptide cycloprolylglycine.
Об авторах
P. Povarnina
Laboratory of Peptide Bioregulators
Автор, ответственный за переписку.
Email: povarnina@gmail.com
Россия, Moscow
K. Kolyasnikova
Laboratory of Peptide Bioregulators
Email: povarnina@gmail.com
Россия, Moscow
S. Nikolaev
Laboratory of Pharmacology of Neuroprotection, V. V. Zakusov Research Institute of Pharmacology
Email: povarnina@gmail.com
Россия, Moscow
T. Antipova
Laboratory of Pharmacology of Neuroprotection, V. V. Zakusov Research Institute of Pharmacology
Email: povarnina@gmail.com
Россия, Moscow
T. Gudasheva
Laboratory of Peptide Bioregulators
Email: povarnina@gmail.com
Россия, Moscow