Email this article Comparative Analysis of Secretome of Human Umbilical Cord- and Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells
- Authors: Romanov Y.A.1,2, Volgina N.E.3, Vtorushina V.V.3, Romanov A.Y.3, Dugina T.N.2, Kabaeva N.V.1, Sukhikh G.T.3
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Affiliations:
- National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation
- Cord Blood Bank “CryoCenter”
- V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Issue: Vol 166, No 4 (2019)
- Pages: 535-540
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241160
- DOI: https://doi.org/10.1007/s10517-019-04388-1
- ID: 241160
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Abstract
Production of cytokines and growth factors by cultured human umbilical cord tissue- and bone marrow-derived multipotent mesenchymal stromal cells was measured by multiplex analysis. In most cases, the concentrations of bioactive factors in the culture medium conditioned by umbilical cord-derived cells was ten- to hundred-times higher than in the medium conditioned by bone marrow-derived cells. These results suggest that both multipotent mesenchymal stromal cells from the umbilical cord and cell-free products can have more pronounced therapeutic effect in comparison with mesenchymal stromal cells obtained from “adult” sources.
About the authors
Yu. A. Romanov
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation; Cord Blood Bank “CryoCenter”
Author for correspondence.
Email: romanov@cryocenter.ru
Russian Federation, Moscow; Moscow
N. E. Volgina
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: romanov@cryocenter.ru
Russian Federation, Moscow
V. V. Vtorushina
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: romanov@cryocenter.ru
Russian Federation, Moscow
A. Yu. Romanov
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: romanov@cryocenter.ru
Russian Federation, Moscow
T. N. Dugina
Cord Blood Bank “CryoCenter”
Email: romanov@cryocenter.ru
Russian Federation, Moscow
N. V. Kabaeva
National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation
Email: romanov@cryocenter.ru
Russian Federation, Moscow
G. T. Sukhikh
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: romanov@cryocenter.ru
Russian Federation, Moscow
