Email this article Chronopharmacological Characteristics of the Effect of Hepatoprotectors in Experiment?
- Authors: Bunyatyan N.D.1, Kal’ko E.A.2, Drogovoz S.M.2, Kononenko A.V.2
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Affiliations:
- I. M. Sechenov First Moscow Medical University, the Ministry of Health of Russia
- National Pharmaceutical University
- Issue: Vol 165, No 6 (2018)
- Pages: 754-757
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240725
- DOI: https://doi.org/10.1007/s10517-018-4258-8
- ID: 240725
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Abstract
We studied circadian rhythms of activity of hepatoprotectors (Antral, Carsil, and glutargin) under conditions of acute paracetamol-induced hepatitis simulated in the morning, afternoon, evening, and at night (09.00, 15.00, 21.00, and 03.00). Antral and Carsil exhibited similar chronoprofiles with the maximum hepatoprotective activity at 09.00 and 21.00, while glutargin exhibited circadian pattern opposite and its activity was maximum at 15.00 and 03.00.
About the authors
N. D. Bunyatyan
I. M. Sechenov First Moscow Medical University, the Ministry of Health of Russia
Author for correspondence.
Email: ndbun@mail.ru
Russian Federation, Moscow
E. A. Kal’ko
National Pharmaceutical University
Email: ndbun@mail.ru
Ukraine, Kharkov
S. M. Drogovoz
National Pharmaceutical University
Email: ndbun@mail.ru
Ukraine, Kharkov
A. V. Kononenko
National Pharmaceutical University
Email: ndbun@mail.ru
Ukraine, Kharkov
