Chronopharmacological Characteristics of the Effect of Hepatoprotectors in Experiment?

N. D. Bunyatyan; E. A. Kal’ko; S. M. Drogovoz; A. V. Kononenko

doi:10.1007/s10517-018-4258-8

Chronopharmacological Characteristics of the Effect of Hepatoprotectors in Experiment?

Authors: Bunyatyan N.D.¹, Kal’ko E.A.², Drogovoz S.M.², Kononenko A.V.²
Affiliations:
1. I. M. Sechenov First Moscow Medical University, the Ministry of Health of Russia
2. National Pharmaceutical University
Issue: Vol 165, No 6 (2018)
Pages: 754-757
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/240725
DOI: https://doi.org/10.1007/s10517-018-4258-8
ID: 240725

Cite item

Full Text

Open Access
Restricted Access

Access granted
Restricted Access

Subscription Access

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

We studied circadian rhythms of activity of hepatoprotectors (Antral, Carsil, and glutargin) under conditions of acute paracetamol-induced hepatitis simulated in the morning, afternoon, evening, and at night (09.00, 15.00, 21.00, and 03.00). Antral and Carsil exhibited similar chronoprofiles with the maximum hepatoprotective activity at 09.00 and 21.00, while glutargin exhibited circadian pattern opposite and its activity was maximum at 15.00 and 03.00.