Chronopharmacological Characteristics of the Effect of Hepatoprotectors in Experiment?
- 作者: Bunyatyan N.1, Kal’ko E.2, Drogovoz S.2, Kononenko A.2
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隶属关系:
- I. M. Sechenov First Moscow Medical University, the Ministry of Health of Russia
- National Pharmaceutical University
- 期: 卷 165, 编号 6 (2018)
- 页面: 754-757
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240725
- DOI: https://doi.org/10.1007/s10517-018-4258-8
- ID: 240725
如何引用文章
详细
We studied circadian rhythms of activity of hepatoprotectors (Antral, Carsil, and glutargin) under conditions of acute paracetamol-induced hepatitis simulated in the morning, afternoon, evening, and at night (09.00, 15.00, 21.00, and 03.00). Antral and Carsil exhibited similar chronoprofiles with the maximum hepatoprotective activity at 09.00 and 21.00, while glutargin exhibited circadian pattern opposite and its activity was maximum at 15.00 and 03.00.
作者简介
N. Bunyatyan
I. M. Sechenov First Moscow Medical University, the Ministry of Health of Russia
编辑信件的主要联系方式.
Email: ndbun@mail.ru
俄罗斯联邦, Moscow
E. Kal’ko
National Pharmaceutical University
Email: ndbun@mail.ru
乌克兰, Kharkov
S. Drogovoz
National Pharmaceutical University
Email: ndbun@mail.ru
乌克兰, Kharkov
A. Kononenko
National Pharmaceutical University
Email: ndbun@mail.ru
乌克兰, Kharkov
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