Email this article Blood Serum Levels of Proinflammatory Cytokines (IL-1β, IL-6, TNFα, IL-8, IL-12p70, and IFNγ) in Patients with Uterine Myoma
- Authors: Konenkov V.I.1, Koroleva E.G.1, Orlov N.B.1, Prokof’ev V.F.1, Shevchenko A.V.1, Novikov A.M.1, Dergacheva T.I.1
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Affiliations:
- Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 165, No 5 (2018)
- Pages: 698-701
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240692
- DOI: https://doi.org/10.1007/s10517-018-4245-0
- ID: 240692
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Abstract
We analyzed cytokine profile in blood serum of patients with uterine myoma and revealed significantly reduced level of IFNγ and a tendency towards a decrease in the levels of IL-1β and TNFα; the levels of IL-6, IL-8, and IL-12p70 did not differ from those in healthy women. The drop in the concentrations of factors responsible for inflammation and angiogenesis in tissues are unfavorable for proliferation and differentiation of the uterine tissues.
About the authors
V. I. Konenkov
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk
E. G. Koroleva
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk
N. B. Orlov
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk
V. F. Prokof’ev
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk
A. V. Shevchenko
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk
A. M. Novikov
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk
T. I. Dergacheva
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk
