Blood Serum Levels of Proinflammatory Cytokines (IL-1β, IL-6, TNFα, IL-8, IL-12p70, and IFNγ) in Patients with Uterine Myoma


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Аннотация

We analyzed cytokine profile in blood serum of patients with uterine myoma and revealed significantly reduced level of IFNγ and a tendency towards a decrease in the levels of IL-1β and TNFα; the levels of IL-6, IL-8, and IL-12p70 did not differ from those in healthy women. The drop in the concentrations of factors responsible for inflammation and angiogenesis in tissues are unfavorable for proliferation and differentiation of the uterine tissues.

Об авторах

V. Konenkov

Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: dr-tanja@yandex.ru
Россия, Novosibirsk

E. Koroleva

Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: dr-tanja@yandex.ru
Россия, Novosibirsk

N. Orlov

Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: dr-tanja@yandex.ru
Россия, Novosibirsk

V. Prokof’ev

Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: dr-tanja@yandex.ru
Россия, Novosibirsk

A. Shevchenko

Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: dr-tanja@yandex.ru
Россия, Novosibirsk

A. Novikov

Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: dr-tanja@yandex.ru
Россия, Novosibirsk

T. Dergacheva

Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Автор, ответственный за переписку.
Email: dr-tanja@yandex.ru
Россия, Novosibirsk


© Springer Science+Business Media, LLC, part of Springer Nature, 2018

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