Early Morphological and Functional Reorganization of the Articular Cartilage in Rats with Experimental Osteoarthrosis of Different Genesis
- Authors: Korochina K.V.1, Chernysheva T.V.1, Korochina I.E.1, Polyakova V.S.1, Shamaev S.Y.1
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Affiliations:
- Orenburg State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 165, No 4 (2018)
- Pages: 497-502
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240453
- DOI: https://doi.org/10.1007/s10517-018-4203-x
- ID: 240453
Cite item
Abstract
Peculiarities of the morphology of some phenotypes of experimental osteoarthrosis was studied in experiments on rats. Reorganization of the knee articular cartilage of Wistar rats during aging (age-associated phenotype), obesity (metabolic phenotype), circulatory disturbances (e.g., chronic heart failure), and their combinations (polymorbidity) was studied by hematoxylin and eosin staining, immunohistochemical staining for collagen II and caspase 3, and morphometry. High sensitivity of the cartilage to non-traumatic influence of different anthropomorphic factors was demonstrated; morphological changes in osteoarthrosis of different genesis. The most pronounced pathological changes were observed in polymorbid animals, which allowed developing a new pathogenetically substantiated model of nontraumatic osteoarthrosis.
About the authors
K. V. Korochina
Orenburg State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: kris_kor@inbox.ru
Russian Federation, Orenburg
T. V. Chernysheva
Orenburg State Medical University, Ministry of Health of the Russian Federation
Email: kris_kor@inbox.ru
Russian Federation, Orenburg
I. E. Korochina
Orenburg State Medical University, Ministry of Health of the Russian Federation
Email: kris_kor@inbox.ru
Russian Federation, Orenburg
V. S. Polyakova
Orenburg State Medical University, Ministry of Health of the Russian Federation
Email: kris_kor@inbox.ru
Russian Federation, Orenburg
S. Yu. Shamaev
Orenburg State Medical University, Ministry of Health of the Russian Federation
Email: kris_kor@inbox.ru
Russian Federation, Orenburg
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