Early Morphological and Functional Reorganization of the Articular Cartilage in Rats with Experimental Osteoarthrosis of Different Genesis
- Авторлар: Korochina K.1, Chernysheva T.1, Korochina I.1, Polyakova V.1, Shamaev S.1
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Мекемелер:
- Orenburg State Medical University, Ministry of Health of the Russian Federation
- Шығарылым: Том 165, № 4 (2018)
- Беттер: 497-502
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240453
- DOI: https://doi.org/10.1007/s10517-018-4203-x
- ID: 240453
Дәйексөз келтіру
Аннотация
Peculiarities of the morphology of some phenotypes of experimental osteoarthrosis was studied in experiments on rats. Reorganization of the knee articular cartilage of Wistar rats during aging (age-associated phenotype), obesity (metabolic phenotype), circulatory disturbances (e.g., chronic heart failure), and their combinations (polymorbidity) was studied by hematoxylin and eosin staining, immunohistochemical staining for collagen II and caspase 3, and morphometry. High sensitivity of the cartilage to non-traumatic influence of different anthropomorphic factors was demonstrated; morphological changes in osteoarthrosis of different genesis. The most pronounced pathological changes were observed in polymorbid animals, which allowed developing a new pathogenetically substantiated model of nontraumatic osteoarthrosis.
Авторлар туралы
K. Korochina
Orenburg State Medical University, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: kris_kor@inbox.ru
Ресей, Orenburg
T. Chernysheva
Orenburg State Medical University, Ministry of Health of the Russian Federation
Email: kris_kor@inbox.ru
Ресей, Orenburg
I. Korochina
Orenburg State Medical University, Ministry of Health of the Russian Federation
Email: kris_kor@inbox.ru
Ресей, Orenburg
V. Polyakova
Orenburg State Medical University, Ministry of Health of the Russian Federation
Email: kris_kor@inbox.ru
Ресей, Orenburg
S. Shamaev
Orenburg State Medical University, Ministry of Health of the Russian Federation
Email: kris_kor@inbox.ru
Ресей, Orenburg
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