Early Morphological and Functional Reorganization of the Articular Cartilage in Rats with Experimental Osteoarthrosis of Different Genesis
- 作者: Korochina K.1, Chernysheva T.1, Korochina I.1, Polyakova V.1, Shamaev S.1
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隶属关系:
- Orenburg State Medical University, Ministry of Health of the Russian Federation
- 期: 卷 165, 编号 4 (2018)
- 页面: 497-502
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240453
- DOI: https://doi.org/10.1007/s10517-018-4203-x
- ID: 240453
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详细
Peculiarities of the morphology of some phenotypes of experimental osteoarthrosis was studied in experiments on rats. Reorganization of the knee articular cartilage of Wistar rats during aging (age-associated phenotype), obesity (metabolic phenotype), circulatory disturbances (e.g., chronic heart failure), and their combinations (polymorbidity) was studied by hematoxylin and eosin staining, immunohistochemical staining for collagen II and caspase 3, and morphometry. High sensitivity of the cartilage to non-traumatic influence of different anthropomorphic factors was demonstrated; morphological changes in osteoarthrosis of different genesis. The most pronounced pathological changes were observed in polymorbid animals, which allowed developing a new pathogenetically substantiated model of nontraumatic osteoarthrosis.
作者简介
K. Korochina
Orenburg State Medical University, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: kris_kor@inbox.ru
俄罗斯联邦, Orenburg
T. Chernysheva
Orenburg State Medical University, Ministry of Health of the Russian Federation
Email: kris_kor@inbox.ru
俄罗斯联邦, Orenburg
I. Korochina
Orenburg State Medical University, Ministry of Health of the Russian Federation
Email: kris_kor@inbox.ru
俄罗斯联邦, Orenburg
V. Polyakova
Orenburg State Medical University, Ministry of Health of the Russian Federation
Email: kris_kor@inbox.ru
俄罗斯联邦, Orenburg
S. Shamaev
Orenburg State Medical University, Ministry of Health of the Russian Federation
Email: kris_kor@inbox.ru
俄罗斯联邦, Orenburg
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