Email this article Subpopulation Structure of IFNγ-Producing T Lymphocytes in Patients with Pulmonary Tuberculosis
- Authors: Kononova T.E.1, Urazova O.I.1, Novitskii V.V.1, Esimova I.E.1, Churina E.G.1,2
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Affiliations:
- Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
- Laboratory of Translational and Cellular Biomedicine, National Research Tomsk State University
- Issue: Vol 165, No 3 (2018)
- Pages: 311-314
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240257
- DOI: https://doi.org/10.1007/s10517-018-4157-z
- ID: 240257
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Abstract
The study of subpopulation structure of IFNγ-producing T cells in patients with pulmonary tuberculosis revealed a decrease in the number of CD3+ IFNγ+ cells against the background of significantly increased IFNγ secretion in vitro irrespective of the clinical form of the disease and drug sensitivity of M. tuberculosis, most strongly expressed in case of the disseminated tuberculosis. In patients with infiltrative drug-sensitive and drug-resistant pulmonary tuberculosis, increased number of Th1/Th17 lymphocytes (CD4+ IFNγ+IL-17A+) and, conversely, decreased number of blood γδT cells was detected.
About the authors
T. E. Kononova
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: kononova.te@gmail.com
Russian Federation, Tomsk
O. I. Urazova
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Email: kononova.te@gmail.com
Russian Federation, Tomsk
V. V. Novitskii
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Email: kononova.te@gmail.com
Russian Federation, Tomsk
I. E. Esimova
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Email: kononova.te@gmail.com
Russian Federation, Tomsk
E. G. Churina
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation; Laboratory of Translational and Cellular Biomedicine, National Research Tomsk State University
Email: kononova.te@gmail.com
Russian Federation, Tomsk; Tomsk
