Subpopulation Structure of IFNγ-Producing T Lymphocytes in Patients with Pulmonary Tuberculosis
- 作者: Kononova T.1, Urazova O.1, Novitskii V.1, Esimova I.1, Churina E.1,2
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隶属关系:
- Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
- Laboratory of Translational and Cellular Biomedicine, National Research Tomsk State University
- 期: 卷 165, 编号 3 (2018)
- 页面: 311-314
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240257
- DOI: https://doi.org/10.1007/s10517-018-4157-z
- ID: 240257
如何引用文章
详细
The study of subpopulation structure of IFNγ-producing T cells in patients with pulmonary tuberculosis revealed a decrease in the number of CD3+ IFNγ+ cells against the background of significantly increased IFNγ secretion in vitro irrespective of the clinical form of the disease and drug sensitivity of M. tuberculosis, most strongly expressed in case of the disseminated tuberculosis. In patients with infiltrative drug-sensitive and drug-resistant pulmonary tuberculosis, increased number of Th1/Th17 lymphocytes (CD4+ IFNγ+IL-17A+) and, conversely, decreased number of blood γδT cells was detected.
作者简介
T. Kononova
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: kononova.te@gmail.com
俄罗斯联邦, Tomsk
O. Urazova
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Email: kononova.te@gmail.com
俄罗斯联邦, Tomsk
V. Novitskii
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Email: kononova.te@gmail.com
俄罗斯联邦, Tomsk
I. Esimova
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Email: kononova.te@gmail.com
俄罗斯联邦, Tomsk
E. Churina
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation; Laboratory of Translational and Cellular Biomedicine, National Research Tomsk State University
Email: kononova.te@gmail.com
俄罗斯联邦, Tomsk; Tomsk
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