Enviar artigo por via de e-mail Subpopulation Structure of IFNγ-Producing T Lymphocytes in Patients with Pulmonary Tuberculosis
- Autores: Kononova T.1, Urazova O.1, Novitskii V.1, Esimova I.1, Churina E.1,2
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Afiliações:
- Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
- Laboratory of Translational and Cellular Biomedicine, National Research Tomsk State University
- Edição: Volume 165, Nº 3 (2018)
- Páginas: 311-314
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240257
- DOI: https://doi.org/10.1007/s10517-018-4157-z
- ID: 240257
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Resumo
The study of subpopulation structure of IFNγ-producing T cells in patients with pulmonary tuberculosis revealed a decrease in the number of CD3+ IFNγ+ cells against the background of significantly increased IFNγ secretion in vitro irrespective of the clinical form of the disease and drug sensitivity of M. tuberculosis, most strongly expressed in case of the disseminated tuberculosis. In patients with infiltrative drug-sensitive and drug-resistant pulmonary tuberculosis, increased number of Th1/Th17 lymphocytes (CD4+ IFNγ+IL-17A+) and, conversely, decreased number of blood γδT cells was detected.
Sobre autores
T. Kononova
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: kononova.te@gmail.com
Rússia, Tomsk
O. Urazova
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Email: kononova.te@gmail.com
Rússia, Tomsk
V. Novitskii
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Email: kononova.te@gmail.com
Rússia, Tomsk
I. Esimova
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation
Email: kononova.te@gmail.com
Rússia, Tomsk
E. Churina
Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation; Laboratory of Translational and Cellular Biomedicine, National Research Tomsk State University
Email: kononova.te@gmail.com
Rússia, Tomsk; Tomsk
