Email this article Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes
- Authors: Nikulin S.V.1,2, Raigorodskaya M.P.1, Poloznikov A.A.1, Zakharova G.S.1, Schumacher U.3, Wicklein D.3, Stürken C.3, Riecken K.3, Fomicheva K.A.4, Alekseev B.Y.4, Shkurnikov M.Y.4
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Affiliations:
- BioClinicum Center
- Moscow Institute of Physics and Technology (MIPT)
- University Medical Center Hamburg-Eppendorf
- P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
- Issue: Vol 164, No 5 (2018)
- Pages: 650-654
- Section: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/239813
- DOI: https://doi.org/10.1007/s10517-018-4051-8
- ID: 239813
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Abstract
Protein IGFBP6 plays an important role in the pathogenesis of many malignant tumors, including breast cancer. The relationship between IGFBP6 protein and the expression of genes associated with the epithelial-mesenchymal transition is studied. Gene IGFBP6 knockdown does not trigger the epithelial-mesenchymal transition in MDA-MB-231 cells, but modifies significantly the expression of many genes involved in this process. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug.
About the authors
S. V. Nikulin
BioClinicum Center; Moscow Institute of Physics and Technology (MIPT)
Email: byalekseev@mail.ru
Russian Federation, Moscow; Moscow
M. P. Raigorodskaya
BioClinicum Center
Email: byalekseev@mail.ru
Russian Federation, Moscow
A. A. Poloznikov
BioClinicum Center
Email: byalekseev@mail.ru
Russian Federation, Moscow
G. S. Zakharova
BioClinicum Center
Email: byalekseev@mail.ru
Russian Federation, Moscow
U. Schumacher
University Medical Center Hamburg-Eppendorf
Email: byalekseev@mail.ru
Germany, Hamburg
D. Wicklein
University Medical Center Hamburg-Eppendorf
Email: byalekseev@mail.ru
Germany, Hamburg
C. Stürken
University Medical Center Hamburg-Eppendorf
Email: byalekseev@mail.ru
Germany, Hamburg
K. Riecken
University Medical Center Hamburg-Eppendorf
Email: byalekseev@mail.ru
Germany, Hamburg
K. A. Fomicheva
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Email: byalekseev@mail.ru
Russian Federation, Moscow
B. Ya. Alekseev
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: byalekseev@mail.ru
Russian Federation, Moscow
M. Yu. Shkurnikov
P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Email: byalekseev@mail.ru
Russian Federation, Moscow
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